If you are configuring the database connection in Content Manager to connect to a Microsoft SQL Server 2005 database, and it’s on a domain and/or you have a specific instance you want to use, you’ll need to modify the “Connection Options” field as shown below:

Where yourdomain is the name of the domain.
If your database has a specific instance you want to use, then add this:
instance=myinstance
Where myinstance is the name of the instance you want to use.
If you want to use these options together, then you would use:
domain=yourdomain, instance=myinstance